Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.

doi:10.1038/sj.ejhg.5201879

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Article

Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.

European journal of human genetics : EJHG - 1 Oct 2007

Majorczyk Edyta, Jasek Monika, Płoski Rafał, Wagner Marta, Kosior Anna, Pawlik Andrzej, Obojski Andrzej, Luszczek Wioleta, Nowak Izabela, Wiśniewski Andrzej, Kuśnierczyk Piotr

Abstract excerpt

PTPN22 gene encodes a lymphoid tyrosine phosphatase (LYP), an important negative regulator of T-cell responses. The 1858C>T (Arg620Trp) single nucleotide polymorphism (rs2476601) was found associated with autoimmune diseases, including rheumatoid arthritis (RA). Allergic diseases are similar to autoimmune diseases, by an exaggerated immune response to an antigen (allergen in this case) normally not invoking such...

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PMID: 17579671
DOI: 10.1038/sj.ejhg.5201879

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PTPN22

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Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.PMID 17579671Read ↗

The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico.Semantic proximity Read ↗

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Association of PTPN22 1858C→T polymorphism, HLA-DRB1 shared epitope and autoantibodies with rheumatoid arthritis.Semantic proximity Read ↗

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The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.Semantic proximity Read ↗

PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.Semantic proximity Read ↗

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