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Amyloid beta enhances cytosolic phospholipase A2 level and arachidonic acid release via nitric oxide in APP-transfected PC12 cells.

Acta biochimica Polonica - 1 Jan 2007

Chalimoniuk Małgorzata, Stolecka Anna, Cakała Magdalena, Hauptmann Susane, Schulz Kris, Lipka Uta, Leuner Kristine, Eckert Anne, Muller Walter E, Strosznajder Joanna B

Abstract excerpt

Cytosolic phospholipase A2 (cPLA2) preferentially liberates arachidonic acid (AA), which is known to be elevated in Alzheimer's disease (AD). The aim of this study was to investigate the possible relationship between enhanced nitric oxide (NO) generation observed in AD and cPLA2 protein level, phosphorylation, and AA release in rat pheochromocytoma cell lines (PC12) differing in amyloid beta secretion. PC12...

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PMID: 17713604

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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