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Article

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011

Müller Marioly, Cárdenas César, Mei Lijuan, Cheung King-Ho, Foskett J Kevin

Abstract excerpt

Mutations in presenilins (PS) account for most early-onset familial Alzheimer's disease (FAD). Accumulating evidence suggests that disrupted Ca(2+) signaling may play a proximal role in FAD specifically, and Alzheimer's disease (AD) more generally, but its links to the pathogenesis of AD are obscure. Here we demonstrate that expression of FAD mutant PS constitutively activates the transcription factor cAMP...

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Identifiers

PMID: 21784978
DOI: 10.1073/pnas.1109297108
PMCID: PMC3156223

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