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Article

Transmembrane glycine zippers: physiological and pathological roles in membrane proteins.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2005

Kim Sanguk, Jeon Tae-Joon, Oberai Amit, Yang Duan, Schmidt Jacob J, Bowie James U

Abstract excerpt

We have observed a common sequence motif in membrane proteins, which we call a glycine zipper. Glycine zipper motifs are strongly overrepresented and conserved in membrane protein sequences, and mutations in glycine zipper motifs are deleterious to function in many cases. The glycine zipper has a significant structural impact, engendering a strong driving force for right-handed packing against a neighboring...

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Identifiers

PMID: 16179394
DOI: 10.1073/pnas.0501234102
PMCID: PMC1242278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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