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Glycine at Position 93 in SOD1: Mutation-Sensitivity Landscape and Context-Dependent Folding Requirements.

Biochemistry - 17 Feb 2026

Nam Min-Kyung, Tserennadmid Battur, Jeong Gi Heon, Kang Seongman, Rhim Hyangshuk

Abstract excerpt

Glycine, the simplest amino acid with a single hydrogen atom as its side chain, plays a crucial role in protein folding and structural flexibility. In this study, we used copper/zinc superoxide dismutase (SOD1) as a model system to investigate how the substitution of glycine at position 93 with various amino acids affects the protein structure and stability. We engineered 19 G93 SOD1 mutants and evaluated their...

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Identifiers

PMID: 41626800
DOI: 10.1021/acs.biochem.5c00583

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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