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Article

Molecular mechanism of ZER1-mediated recognition of N-terminal glycine in protein degradation.

Journal of biomolecular structure & dynamics - 1 Apr 2026

Liu Chengeng, Zhang Shun, Hao Xiafei, Zhao Xule, Zhang Yanjun, Fan Feng

Abstract excerpt

The N-terminal glycine (Gly/N-degron) serves as a degradation signal recognized by specific E3 ligases, playing a crucial role in protein quality control and maintaining intracellular protein homeostasis. Zinc finger E3 ubiquitin protein ligase 1 (ZER1), a substrate receptor of the Cullin 2-RING E3 ubiquitin ligase, recognizes N-terminal glycine and other small N-terminal residues (such as serine, alanine, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40108959
DOI: 10.1080/07391102.2025.2475222

Genes

ZER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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