Aromatic rescue of glycine in beta sheets.

doi:10.1016/s1359-0278(98)00062-5

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Article

Aromatic rescue of glycine in beta sheets.

Folding & design - 1 Jan 1998

Merkel J S, Regan L

Abstract excerpt

BACKGROUND: Glycine is an intrinsically destabilizing residue in beta sheets. In natural proteins, however, this destabilization can be 'rescued' by specific cross-strand pairing with aromatic residues. Here, we present an experimental study of this effect. RESULTS: Protein variants containing gl...

Topics

Animals
Glycine
Models, Molecular
Mutation
Protein Folding
Proteins
Thermodynamics

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