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Article

Filopodia formation driven by membrane glycoprotein M6a depends on the interaction of its transmembrane domains.

Journal of neurochemistry - 1 Aug 2015

Formoso Karina, García Micaela D, Frasch Alberto C, Scorticati Camila

Abstract excerpt

Membrane glycoprotein M6a, which belongs to the tetraspan proteolipid protein family, promotes structural plasticity in neurons and cell lines by unknown mechanisms. This glycoprotein is encoded by Gpm6a, a stress-regulated gene. The hippocampus of animals chronically stressed by either psychosocial or physical stressors shows decreased M6a expression. Stressed Gpm6a-null mice develop a claustrophobia-like...

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Identifiers

PMID: 25940868
DOI: 10.1111/jnc.13153

Genes

PLP1

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