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Article

Genomic and molecular landscape of gallbladder cancer elucidating pathogenic mechanisms novel therapeutic targets and clinical implications.

Mutation research - 1 Jan 2025

Kumar Manishankar, Kumar Arun, Srivastav Abhinav, Ghosh Ashok, Kumar Dhruv

Abstract excerpt

Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis, often diagnosed at advanced stages due to subtle early symptoms. Recent studies have provided a comprehensive view of GBC's genetic and mutational landscape, uncovering crucial pathways involved in its pathogenesis. Environmental exposures, particularly to heavy metals, have been linked to elevated GBC risk. Established signaling...

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Source

Identifiers

PMID: 39754821
DOI: 10.1016/j.mrfmmm.2024.111896

Genes

BRAF
CDKN2A
IDH1
KRAS
MET
MGMT
MYC
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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