Article
Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis.
The Journal of biological chemistry - 5 Jun 2015
Rahman Md Aejazur, Sobia Parveen, Dwivedi Ved Prakash, Bhawsar Aakansha, Singh Dhiraj Kumar, Sharma Pawan, Moodley Prashini, Van Kaer Luc, Bishai William R, Das Gobardhan
Abstract excerpt
Mycobacterium tuberculosis, the causative agent of tuberculosis, is an ancient pathogen and a major cause of death worldwide. Although various virulence factors of M. tuberculosis have been identified, its pathogenesis remains incompletely understood. TlyA is a virulence factor in several bacterial infections and is evolutionarily conserved in many Gram-positive bacteria, but its function in M. tuberculosis...
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