Article
P fimbriae-dependent, lipopolysaccharide-independent activation of epithelial cytokine responses.
Molecular microbiology - 1 Aug 1999
Hedlund M, Wachtler C, Johansson E, Hang L, Somerville J E, Darveau R P, Svanborg C
Abstract excerpt
Cells in the mucosal barrier are equipped to sense and respond to microbes in the lumen and translate this molecular information into signals that can reach local or distant sites. The interaction of P-fimbriated Escherichia coli with human uroepithelial cells is a model to study the molecular mechanism of epithelial cell activation by mucosal pathogens. Here, we examine the role of lipopolysaccharide (LPS) as a...
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