A familial Alzheimer's disease locus on chromosome 1.

doi:10.1126/science.7638621

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Article

A familial Alzheimer's disease locus on chromosome 1.

Science (New York, N.Y.) - 18 Aug 1995

Levy-Lahad E, Wijsman E M, Nemens E, Anderson L, Goddard K A, Weber J L, Bird T D, Schellenberg G D

Abstract excerpt

The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 1
Female
Genetic Markers
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germany

Haplotypes

Humans

Lod Score

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 7638621
DOI: 10.1126/science.7638621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7638621-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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