PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.

doi:10.1086/468189

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Article

PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.

American journal of human genetics - 1 Oct 2005

Carlton Victoria E H, Hu Xiaolan, Chokkalingam Anand P, Schrodi Steven J, Brandon Rhonda, Alexander Heather C, Chang Monica, Catanese Joseph J, Leong Diane U, Ardlie Kristin G, Kastner Daniel L, Seldin Michael F, Criswell Lindsey A, Gregersen Peter K, Beasley Ellen, Thomson Glenys, Amos Christopher I, Begovich Ann B

Abstract excerpt

The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein tyrosine phosphatase gene, PTPN22, has been associated with multiple autoimmune diseases, including rheumatoid arthritis (RA). These genetic data, combined with biochemica...

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Identifiers

PMID: 16175503
DOI: 10.1086/468189
PMCID: PMC1275606

Genes

PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16175503-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.PMID 16175503Read ↗

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Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.Semantic proximity Read ↗

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