Article
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
American journal of human genetics - 1 Aug 2004
Begovich Ann B, Carlton Victoria E H, Honigberg Lee A, Schrodi Steven J, Chokkalingam Anand P, Alexander Heather C, Ardlie Kristin G, Huang Qiqing, Smith Ashley M, Spoerke Jill M, Conn Marion T, Chang Monica, Chang Sheng-Yung P, Saiki Randall K, Catanese Joseph J, Leong Diane U, Garcia Veronica E, McAllister Linda B, Jeffery Douglas A, Lee Annette T, Batliwalla Franak, Remmers Elaine, Criswell Lindsey A, Seldin Michael F, Kastner Daniel L, Amos Christopher I, Sninsky John J, Gregersen Peter K
Abstract excerpt
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting approximately 1% of the adult population worldwide, with an estimated heritability of 60%. To identify genes involved in RA susceptibility, we investigated the association between putative functional single-nucleotide polymorphisms (SNPs) and RA among white individuals by use of a case-control study design; a second sample was...
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