Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.

doi:10.3899/jrheum.110361

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Article

Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.

The Journal of rheumatology - 1 Nov 2011

Martín Jose-Ezequiel, Alizadeh Behrooz Z, González-Gay Miguel A, Balsa Alejandro, Pascual-Salcedo Dora, González-Escribano María F, Rodriguez-Rodriguez Luis, Fernández-Gutiérrez Benjamín, Raya Enrique, Coenen Marieke J H, van Riel Piet, Radstake Timothy R D J, Kvien Tore K, Viken Marte K, Lie Benedicte A, Koeleman Bobby P C, Martín Javier

Abstract excerpt

OBJECTIVE: The PTPN22 rs2476601 genetic variant has been associated with rheumatoid arthritis (RA) and other autoimmune diseases. Some reports suggest that this single-nucleotide polymorphism (SNP) may not be the only causal variant in the region of PTPN22. Our aim was to identify new independent RA-associated common gene variants in the PTPN22 region. METHODS: We analyzed Wellcome Trust Case-Control Consortium...

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PMID: 21965649
DOI: 10.3899/jrheum.110361

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PTPN22

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Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.PMID 21965649Read ↗

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