Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.

doi:10.1136/gut.2009.194787

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Article

Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.

Gut - 1 Nov 2010

Svrcek Magali, Buhard Olivier, Colas Chrystelle, Coulet Florence, Dumont Sylvie, Massaoudi Illiasse, Lamri Amel, Hamelin Richard, Cosnes Jacques, Oliveira Carla, Seruca Raquel, Gaub Marie-Pierre, Legrain Michèle, Collura Ada, Lascols Olivier, Tiret Emmanuel, Fléjou Jean-François, Duval Alex

Abstract excerpt

BACKGROUND AND AIMS: O(6)-Methylguanine-DNA methyltransferase (MGMT) removes methyl adducts from O(6)-guanine. Known as methylation tolerance, selection for mismatch repair (MMR)-deficient cells that are unable to initiate lethal processing of O(6)-methylguanine-induced mismatches in DNA is observed in vitro as a consequence of MGMT deficiency. It was therefore hypothesised that an MGMT field defect may...

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PMID: 20947886
DOI: 10.1136/gut.2009.194787

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MGMT

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