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Article

Distribution of the strength of selection against amino acid replacements in human proteins.

Human molecular genetics - 1 Nov 2005

Yampolsky Lev Y, Kondrashov Fyodor A, Kondrashov Alexey S

Abstract excerpt

The impact of an amino acid replacement on the organism's fitness can vary from lethal to selectively neutral and even, in rare cases, beneficial. Substantial data are available on either pathogenic or acceptable replacements. However, the whole distribution of coefficients of selection against individual replacements is not known for any organism. To ascertain this distribution for human proteins, we combined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16174645
DOI: 10.1093/hmg/ddi350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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