Selective pressures at a codon-level predict deleterious mutations in human disease genes.

doi:10.1016/j.jmb.2006.02.067

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Selective pressures at a codon-level predict deleterious mutations in human disease genes.

Journal of molecular biology - 19 May 2006

Arbiza Leonardo, Duchi Serena, Montaner David, Burguet Jordi, Pantoja-Uceda David, Pineda-Lucena Antonio, Dopazo Joaquín, Dopazo Hernán

Abstract excerpt

Deleterious mutations affecting biological function of proteins are constantly being rejected by purifying selection from the gene pool. The non-synonymous/synonymous substitution rate ratio (omega) is a measure of selective pressure on amino acid replacement mutations for protein-coding genes. Different methods have been developed in order to predict non-synonymous changes affecting gene function. However, none...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Databases, Genetic
Share to Genes, p53
Share to Genetic Diseases, Inborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Proteins

Share to Selection, Genetic

Share to Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 16584746
DOI: 10.1016/j.jmb.2006.02.067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.