Article

Pathogenic amino acids in mitochondrial proteins more frequently arise in lineages closely related to human than in distant lineages

2017-03-23

Abstract excerpt

Propensities for different amino acids within a protein site change in the course of evolution, so that an amino acid deleterious in a particular species may be acceptable at the same site in a different species. Here, we study the amino acid-changing variants in human mitochondrial genes, and analyze their occurrence in non-human species. We show that substitutions giving rise to the human amino acid variant tend...

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Literature Corpus work: 9bb3a7b8-e0c9-594f-9a55-fba5835ae82d
DOI: 10.1101/119792

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