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Article

Strength of the purifying selection against different categories of the point mutations in the coding regions of the human genome.

Human molecular genetics - 1 Apr 2006

Gorlov Ivan P, Kimmel Marek, Amos Christopher I

Abstract excerpt

Using available Information on the total absolute size of the coding region of the human genome, data on codon usage and pseudogene-derived mutation rates for different single nucleotide substitutions we have estimated, for the human genome, the potential numbers of mutation events capable to produce: (1) nonsense; (2) missense (radical and conservative); (3) silent; (4) splice; and (5) protein-elongating (those...

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Share to Computational Biology
Share to DNA, Recombinant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Mutation, Missense

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 16500998
DOI: 10.1093/hmg/ddl029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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