An estimate on the effect of point mutation and natural selection on the rate of amino acid replacement in proteins.

doi:10.1007/BF02102357

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Article

An estimate on the effect of point mutation and natural selection on the rate of amino acid replacement in proteins.

Journal of molecular evolution - 1 Jan 2000

Frömmel C, Holzhütter H G

Abstract excerpt

We outline a method for estimating quantitatively the influence of point mutations and selection on the frequencies of codons and amino acids. We show how the mutation rate, i.e., the rate of amino acid replacement due to point mutation, can be affected by the codon usage as well as by the rates...

Topics

Amino Acid Sequence
Anticodon
Base Composition
Biological Evolution
Codon
Mathematics
Models, Genetic
Mutation
Probability
Proteins
Selection, Genetic

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