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Article

GST genotype may modify clinical phenotype in patients with Fanconi anaemia.

British journal of haematology - 1 Oct 2005

Davies Stella M, Radloff Gretchen A, DeFor Todd E, Levran Orna, Batish Sat Dev, Hanenberg Helmut, Auerbach Arleen D

Abstract excerpt

In the search for genetic modifiers of the Fanconi anaemia (FA) phenotype, we examined the role of polymorphism in three glutathione s-transferase genes (GSTT1, GSTM1 and GSTP1) in 356 FA patients enrolled in the International Fanconi Anaemia Registry (IFAR). Cellular sensitivity to 1,2:3,4 diepoxybutane was significantly increased in GSTT1 deleted compared with GSTT1 positive cases (median chromosomal breaks...

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Share to Fanconi Anemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 16173971
DOI: 10.1111/j.1365-2141.2005.05721.x

Genes

GSTT1
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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