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Article

Mitomycin C and diepoxybutane action mechanisms and FANCC protein functions: further insights into the role for oxidative stress in Fanconi's anaemia phenotype.

Carcinogenesis - 1 May 2000

Pagano G

Abstract excerpt

Evidence for redox-dependent toxicities of mitomycin C (MMC) and diepoxybutane (DEB), through different mechanisms, has been related to the phenotypic defect(s) of Fanconi's anaemia (FA) cells, due to their excess sensitivity to these agents. Recent data have pointed to interactions of the FANCC protein (encoded by the FA complementation group C gene, FA-C) with NADPH cytochrome P450 reductase and glutathione...

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Source

Identifiers

PMID: 10783335
DOI: 10.1093/carcin/21.5.1067

Genes

FANCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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