Article
Fanconi anaemia proteins: major roles in cell protection against oxidative damage.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 2003
Pagano Giovanni, Youssoufian Hagop
Abstract excerpt
Fanconi anaemia (FA) is a cancer-prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox...
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