Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

American journal of hematology - 1 Oct 2013

Babushok Daria V, Li Yimei, Roth Jacquelyn J, Perdigones Nieves, Cockroft Joshua D, Biegel Jaclyn A, Mason Philip J, Bessler Monica

Abstract excerpt

Acquired aplastic anemia (AA) is a rare life-threatening bone marrow failure syndrome, caused by autoimmune destruction of hematopoietic stem and progenitor cells. Epidemiologic studies suggest that environmental exposures and metabolic gene polymorphisms contribute to disease pathogenesis. Several case-control studies linked homozygous deletion of the glutathione S-transferase theta (GSTT1) gene to AA; however,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Aplastic
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genetic Predisposition to Disease

Share to Glutathione Transferase

Share to Models, Biological

Share to Polymorphism, Genetic

Share to PubMed

Source

Open in PubMed Open full text

Identifiers

PMID: 23798465
DOI: 10.1002/ajh.23521
PMCID: PMC3983712

Genes

GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.PMID 23798465Read ↗

Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children.Semantic proximity Read ↗

Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia.Semantic proximity Read ↗

Association of GSTM1 and GSTT1 deletion polymorphisms with Pakistani aplastic anemia patients and controls and meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms of glutathione-S-transferase and microsomal epoxide hydrolase in egyptian acquired aplastic anemia patients.Semantic proximity Read ↗

Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India.Semantic proximity Read ↗

Polymorphisms of the TGF-β1 gene and the risk of acquired aplastic anemia in a Chinese population.Semantic proximity Read ↗

Gluthatione-S-transferase T1-null genotype predisposes adults to acute promyelocytic leukemia; a case-control study.Semantic proximity Read ↗

Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking glutathione S-transferase genes.Semantic proximity Read ↗

Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects.Semantic proximity Read ↗

Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients.Semantic proximity Read ↗

Influence of GSTM1, GSTT1, and GSTP1 genetic polymorphisms on disorders in transplant patients: a systematic review.Semantic proximity Read ↗

The complex pathophysiology of acquired aplastic anaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.