Article
Individual sensitivity to cytogenetic effects of 1,2:3,4-diepoxybutane in cultured human lymphocytes: influence of glutathione S-transferase M1, P1 and T1 genotypes.
Pharmacogenetics - 1 Dec 1998
Landi S, Norppa H, Frenzilli G, Cipollini G, Ponzanelli I, Barale R, Hirvonen A
Abstract excerpt
Although some blood parameters have been suggested to modulate in-vitro induction of sister chromatid exchanges by 1,2:3,4-diepoxybutane (DEB), a metabolite of 1,3-butadiene, the increased sensitivity has largely been assigned to a homozygous deletion of glutathione S-transferase T1 gene (GSTT1 n...
Topics
- Adult
- Cells, Cultured
- Chromosome Aberrations
- Epoxy Compounds
- Female
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Lymphocytes
- Male
- Middle Aged
- Mutagens
- Sister Chromatid Exchange