Article
Increased prevalence of GSTM(1) null genotype in patients with myelodysplastic syndrome: a case-control study.
Acta haematologica - 1 Jan 2000
Tsabouri S E, Georgiou I, Alamanos I, Bourantas K L
Abstract excerpt
BACKGROUND AND OBJECTIVE: Myelodysplastic syndromes (MDS) are clonal disorders of bone marrow stem cells characterized by ineffective hematopoiesis leading to blood cytopenia; they often progress to acute myeloid leukemia (AML). The glutathione S-transferases (GST) detoxify various agents, including those implicated in MDS. Both GSTM(1) and GSTT(1) genes have "null" alleles and are polymorphic. We studied the...
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