GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.

doi:10.1080/10245332.2016.1201631

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Article

GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.

Hematology (Amsterdam, Netherlands) - 1 Apr 2017

Abu-Duhier Faisel, Mir Rashid

Abstract excerpt

BACKGROUND: Glutathione system plays an important role in the protection of cells and tissue against damage from oxidative stress. Impairment of the glutathione system due to genetic polymorphism of GST genes may increase the risk and severity of sickle cell disease (SCD). Present study was, therefore, undertaken to examine the relative impact of the genetic polymorphism of GSTT1 and GSTM1 (rs4025935 and...

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Identifiers

PMID: 27885941
DOI: 10.1080/10245332.2016.1201631

Genes

GSTT1
SCD
GSTM1

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