Multilocus LD measure and tagging SNP selection with generalized mutual information.

doi:10.1002/gepi.20092

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Article

Multilocus LD measure and tagging SNP selection with generalized mutual information.

Genetic epidemiology - 1 Dec 2005

Liu Zhenqiu, Lin Shili

Abstract excerpt

Linkage disequilibrium (LD) plays a central role in fine mapping of disease genes and, more recently, in characterizing haplotype blocks. Classical LD measures, such as D' and r(2), are frequently used to quantify relationship between two loci. A pairwise "distance" matrix among a set of loci can be constructed using such a measure, and based upon which a number of haplotype block detection and tagging single...

Topics

Algorithms
Linkage Disequilibrium
Polymorphism, Single Nucleotide

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Identifiers

PMID: 16173096
DOI: 10.1002/gepi.20092
PMCID: PMC2596944

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