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Article

Identification of the critical residues involved in peptidoglycan detection by Nod1.

The Journal of biological chemistry - 18 Nov 2005

Girardin Stephen E, Jéhanno Muguette, Mengin-Lecreulx Dominique, Sansonetti Philippe J, Alzari Pedro M, Philpott Dana J

Abstract excerpt

Nod1 is an intracellular pattern recognition molecule activated following bacterial infection, which senses a specific muropeptide (l-Ala-d-Glu-meso-DAP (diaminopimelic acid); "Tri(DAP)") from peptidoglycan. Here we investigated the molecular basis of Tri(DAP) sensing by human (h) Nod1. Our results identified the domain responsible for Tri(DAP) detection in the center of the concave surface of hNod1 leucine-rich...

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Identifiers

PMID: 16172124
DOI: 10.1074/jbc.M509537200

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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