Article
Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.
Immunity - 17 Oct 2017
Kleino Anni, Ramia Nancy F, Bozkurt Gunes, Shen Yanfang, Nailwal Himani, Huang Jing, Napetschnig Johanna, Gangloff Monique, Chan Francis Ka-Ming, Wu Hao, Li Jixi, Silverman Neal
Abstract excerpt
In the Drosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-κB homolog Relish and robust antimicrobial peptide gene expression. PGRP-LC, PGRP-LE, and Imd each contain a motif with some resemblance to the RIP Homotypic Interaction Motif (RHIM), a domain found...
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