Article
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists.
The Journal of biological chemistry - 28 Oct 2005
Netea Mihai G, Ferwerda Gerben, de Jong Dirk J, Werts Catherine, Boneca Ivo G, Jéhanno Muguette, Van Der Meer Jos W M, Mengin-Lecreulx Dominique, Sansonetti Philippe J, Philpott Dana J, Dharancy Sébastien, Girardin Stephen E
Abstract excerpt
NOD2/CARD15 is the first characterized susceptibility gene in Crohn disease. The Nod2 1007fs (Nod2fs) frameshift mutation is the most prevalent in Crohn disease patients. Muramyl dipeptide from bacterial peptidoglycan is the minimal motif detected by Nod2 but not by Nod2fs. Here we investigated the response of human peripheral blood mononuclear cells (PBMCs) from Crohn disease patients not only to muramyl...
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