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Article

Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism.

The Journal of biological chemistry - 18 Nov 2005

Michlig Stéphanie, Harris Michael, Loffing Johannes, Rossier Bernard C, Firsov Dmitri

Abstract excerpt

Activation of the mitogen-activated protein (MAP) kinase cascade by progesterone in Xenopus oocytes leads to a marked down-regulation of activity of the amiloride-sensitive epithelial sodium channel (ENaC). Here we have studied the signaling pathways involved in progesterone effect on ENaC activity. We demonstrate that: (i) the truncation of the C termini of the alphabetagammaENaC subunits results in the loss of...

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Source

Identifiers

PMID: 16172119
DOI: 10.1074/jbc.M506308200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism.PMID 16172119Read ↗

The phosphorylation site T613 in the β-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4-2.Semantic proximity Read ↗

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Arachidonic acid regulates surface expression of epithelial sodium channels.Semantic proximity Read ↗

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.Semantic proximity Read ↗

Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).Semantic proximity Read ↗

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.Semantic proximity Read ↗

Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway.Semantic proximity Read ↗

Mechanism of Action of Progesterone AntagonistsSemantic proximity Read ↗

Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.Semantic proximity Read ↗

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.Semantic proximity Read ↗

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