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Article

Mechanism of Action of Progesterone Antagonists

1 Dec 2002

Abstract excerpt

The effects of progesterone on target tissues are mediated by progesterone receptors (PRs), which belong to a family of nuclear receptors and function as ligand-activated transcription factors to regulate the expression of specific sets of target genes. Progesterone antagonists repress the biological actions of progesterone by "actively" inhibiting PR activation. This work discusses the first clinically used...

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PMID: 12486206
DOI: 10.1177/153537020222701104

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