Article
Progesterone and estrogen regulate NALCN expression in human myometrial smooth muscle cells.
American journal of physiology. Endocrinology and metabolism - 1 Apr 2020
Amazu Chinwendu, Ma Xiaofeng, Henkes Clara, Ferreira Juan J, Santi Celia M, England Sarah K
Abstract excerpt
During pregnancy, the uterus transitions from a quiescent state to an excitable, highly contractile state to deliver the fetus. Two important contributors essential for this transition are hormones and ion channels, both of which modulate myometrial smooth muscle cell (MSMC) excitability. Recently, the sodium (Na+) leak channel, nonselective (NALCN), was shown to contribute to a Na+ leak current in human MSMCs,...
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