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Article

Arachidonic acid regulates surface expression of epithelial sodium channels.

The Journal of biological chemistry - 19 Sept 2003

Carattino Marcelo D, Hill Warren G, Kleyman Thomas R

Abstract excerpt

Epithelial Na+ channels (ENaCs) are regulated by the phospholipase A2 (PLA2) product arachidonic acid. Pharmacological inhibition of PLA2 with aristolochic acid induced a significant increase in amiloride-sensitive currents in Xenopus oocytes expressing ENaC. Arachidonic acid or 5,8,11,14-eicosatetraynoic acid (ETYA), a non-metabolized analog of arachidonic acid, induced a time-dependent inhibition of Na+...

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Identifiers

PMID: 12837767
DOI: 10.1074/jbc.M300312200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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