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Article

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.

The Journal of biological chemistry - 18 Nov 2005

Stankiewicz Adam R, Lachapelle Guillaume, Foo Cheryl P Z, Radicioni Stefanie M, Mosser Dick D

Abstract excerpt

Hsp70 overexpression can protect cells from stress-induced apoptosis. Our previous observation that Hsp70 inhibits cytochrome c release in heat-stressed cells led us to examine events occurring upstream of mitochondrial disruption. In this study we examined the effects of heat shock on the proapoptotic Bcl-2 family member Bax because of its central role in regulating cytochrome c release in stressed cells. We...

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Identifiers

PMID: 16172114
DOI: 10.1074/jbc.M509497200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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