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Article

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

Nature cell biology - 1 Apr 2003

Sawada Motoshi, Sun Weiyong, Hayes Paulette, Leskov Konstantin, Boothman David A, Matsuyama Shigemi

Abstract excerpt

Bax induces mitochondrial-dependent cell death signals in mammalian cells. However, the mechanism of how Bax is kept inactive has remained unclear. Yeast-based functional screening of Bax inhibitors from mammalian cDNA libraries identified Ku70 as a new Bax suppressor. Bax-mediated apoptosis was suppressed by overexpression of Ku70 in mammalian cells, but enhanced by downregulation of Ku70. We found that Ku70...

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PMID: 12652308
DOI: 10.1038/ncb950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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