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Article

Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.

Molecular biology of the cell - 1 May 2006

Bonzon Christine, Bouchier-Hayes Lisa, Pagliari Lisa J, Green Douglas R, Newmeyer Donald D

Abstract excerpt

The mechanisms through which Caspase-2 leads to cell death are controversial. Here we show, using a combination of cell-free and cell culture-based approaches, that cleavage of the Bcl-2-family protein Bid is required for the induction of apoptosis by Caspase-2. Caspase-2 promoted cytochrome c release from mitochondria in the presence of cytosol from wild-type, but not Bid-deficient, mouse embryonic fibroblasts...

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Share to BH3 Interacting Domain Death Agonist Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16495337
DOI: 10.1091/mbc.e05-12-1107
PMCID: PMC1446087

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Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.PMID 16495337Read ↗

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