Article
Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax.
Biochemical and biophysical research communications - 12 Sept 2003
Tanaka Tetsuhiro, Hanafusa Norio, Ingelfinger Julie R, Ohse Takamoto, Fujita Toshiro, Nangaku Masaomi
Abstract excerpt
Chronic hypoxia is a major contributor to tubulointerstitial injury in various renal diseases and apoptosis is apparently involved. Although many studies report hypoxia-induced apoptosis in cultured tubular cells, information has been limited in proximal tubular cells, those from the most susceptible portion of renal tubules against hypoxia. This study was to confirm a role for apoptosis in hypoxic proximal...
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