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Article

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.

Development (Cambridge, England) - 5 Oct 2020

Najarro Elvis Huarcaya, Huang Jennifer, Jacobo Adrian, Quiruz Lee A, Grillet Nicolas, Cheng Alan G

Abstract excerpt

Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear. Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved. Here, we have used the developing cochlea as a model system to show that...

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Identifiers

PMID: 32907846
DOI: 10.1242/dev.191981
PMCID: PMC7561480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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