Article
Tagging single nucleotide polymorphisms in MBD4 are associated with risk of lung cancer in a Chinese population.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2008
Miao Ruifen, Gu Haiyong, Liu Hongliang, Hu Zhibin, Jin Guangfu, Wang Haifeng, Wang Ying, Sun Weiwei, Ma Hongxia, Chen Dan, Tian Tian, Jin Li, Wei Qingyi, Lu Daru, Huang Wei, Shen Hongbing
Abstract excerpt
MBD4 (methyl-CpG binding domain protein 4) was identified as a methyl-CpG binding protein and plays an important role in DNA methylation and carcinogenesis. We hypothesized that genetic variants in MBD4 were associated with lung cancer risk. We selected and genotyped three tagging SNPs (rs2311394, rs140693, and rs2005618) of MBD4 using the illumina SNP genotyping BeadLab platform in a case-control study of 500...
Read the complete abstract on PubMed