Article
Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals.
Genome biology - 1 Jan 2005
Chamary J V, Hurst Laurence D
Abstract excerpt
BACKGROUND: In mammals, contrary to what is usually assumed, recent evidence suggests that synonymous mutations may not be selectively neutral. This position has proven contentious, not least because of the absence of a viable mechanism. Here we test whether synonymous mutations might be under selection owing to their effects on the thermodynamic stability of mRNA, mediated by changes in secondary structure....
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