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Article

Preliminary assessment of the impact of microRNA-mediated regulation on coding sequence evolution in mammals.

Journal of molecular evolution - 1 Aug 2006

Hurst Laurence D

Abstract excerpt

Despite prior claims to the contrary, several lines of evidence suggest that selection acts on synonymous mutations in mammals. What might be the mechanisms for such selection? Here I attempt to quantify the constraints on the evolution of the coding sequence resulting from regulation of mRNA by microRNAs (miRNAs) that antisense-bind to the coding region of mRNAs. I employ a set of genes recently experimentally...

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PMID: 16786435
DOI: 10.1007/s00239-005-0273-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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