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Article

Macroevolutionary divergence of gene expression driven by selection on protein abundance.

Science (New York, N.Y.) - 7 Mar 2025

Cope Alexander L, Schraiber Joshua G, Pennell Matt

Abstract excerpt

The regulation of messenger RNA (mRNA) and protein abundances is well-studied, but less is known about the evolutionary processes shaping their relationship. To address this, we derived a new phylogenetic model and applied it to multispecies mammalian data. Our analyses reveal (i) strong stabilizing selection on protein abundances over macroevolutionary time, (ii) mutations affecting mRNA abundances minimally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40048509
DOI: 10.1126/science.ads2658
PMCID: PMC12314801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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