Association of single nucleotide polymorphisms in interleukin 12 (IL-12A and -B) with asthma in a Chinese population.

doi:10.1016/j.humimm.2011.03.018

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Article

Association of single nucleotide polymorphisms in interleukin 12 (IL-12A and -B) with asthma in a Chinese population.

Human immunology - 1 Jul 2011

Chen Tianyi, Liang Weibo, Gao Linbo, Wang Yanyun, Liu Yun, Zhang Lushun, Zhang Lin

Abstract excerpt

Increasing evidence has indicated that genetic variants may contribute to immune dysregulation and susceptibility to noninfectious inflammatory diseases. Cytokines, including interleukin 12 (IL-12), play a key role in the regulation of the immune system. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) in IL-12A and IL-12B were associated with asthma in a Chinese population....

Topics

Adult
Alleles
Asian People
Asthma
Case-Control Studies
Female
Gene Frequency
Genotype
Humans
Interleukin-12 Subunit p35
Interleukin-12 Subunit p40
Male
Middle Aged
Polymorphism, Single Nucleotide
Young Adult

Source

Open in PubMed

Identifiers

PMID: 21513752
DOI: 10.1016/j.humimm.2011.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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