Article
Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans.
Journal of dermatological science - 1 Mar 2010
Namkung Jung-Hyun, Lee Jong-Eun, Kim Eugene, Kim Song, Kim Sook, Shin Eun-Soon, Cho Eun-Young, Yang Jun-Mo
Abstract excerpt
BACKGROUND: The acute skin lesions of atopic dermatitis (AD) are associated with Th2 cells; however, the chronic skin lesions of AD are associated with Th1 cells via the action of IL-12. OBJECTIVE: We evaluated the associations of single nucleotide polymorphisms (SNPs) and haplotype in the IL-12 and IL-12 receptor genes, and determined the gene-gene interactions between the SNPs of these genes and the SNPs of the...
Topics
- Adolescent
- Adult
- Alleles
- Asian People
- Blood Cell Count
- Case-Control Studies
- Child
- Child, Preschool
- Dermatitis, Atopic
- Eosinophils
- Epistasis, Genetic
- Female
- Gene Frequency