Article
Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients.
Journal of dermatological science - 1 Nov 2002
Tsunemi Yuichiro, Saeki Hidehisa, Nakamura Koichiro, Sekiya Takashi, Hirai Koichi, Kakinuma Takashi, Fujita Hideki, Asano Noriko, Tanida Yuka, Wakugawa Motoshi, Torii Hideshi, Tamaki Kunihiko
Abstract excerpt
Interleukin (IL)-13 plays an important role in the induction of immunoglobulin E (IgE) and in the pathogenesis of atopic dermatitis (AD). We investigated the allele and genotype frequencies of three IL-13 single nucleotide polymorphisms (SNPs) (A704C and C1103T in the promoter region and G4257A in exon 4) in Japanese patients with AD. For A704C and C1103T SNPs, there were no significant differences in allele or...
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