Article
Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.
Journal of dermatological science - 1 Nov 2002
Tsunemi Yuichiro, Saeki Hidehisa, Nakamura Koichiro, Sekiya Takashi, Hirai Koichi, Fujita Hideki, Asano Noriko, Kishimoto Megumi, Tanida Yuka, Kakinuma Takashi, Mitsui Hiroshi, Tada Yayoi, Wakugawa Motoshi, Torii Hideshi, Komine Mayumi, Asahina Akihiko, Tamaki Kunihiko
Abstract excerpt
Interleukin-12 (IL-12) is believed to play an important role in inducing Th1-type cytokine profiles. Atopic dermatitis (AD) and psoriasis vulgaris (PsV) are considered to be Th2 and Th1 type disease, respectively. The IL-12 p40 subunit gene (IL12B) is located at chromosome 5q31-33 and linkage fin...
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