Article
Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.
Experimental dermatology - 1 Nov 2011
Namkung Jung-Hyun, Lee Jong-Eun, Kim Eugene, Kim Hyun-Je, Seo Eun-Young, Jang Hye-Yoon, Shin Eun-Soon, Cho Eun-Young, Yang Jun-Mo
Abstract excerpt
Th2-dominated immune responses are believed to contribute to the pathogenesis of atopic dermatitis (AD). IL-4 and IL-13 are typical pleiotropic Th2 cytokines that play a central role in IgE-dependent inflammatory reactions. Single-nucleotide polymorphisms (SNPs) in IL-4 and IL-13 have been reported in patients with allergic disease from numerous countries. Gene-gene interactions among genes have been identified...
Topics
- Adolescent
- Adult
- Asian People
- Case-Control Studies
- Child
- Child, Preschool
- Dermatitis, Atopic
- Female
- Gene Frequency
- Genetic Association Studies
- Haplotypes
- Humans
- Infant
- Infant, Newborn